|A Canary's Eye View Metabolic Basis|
|The Defect(s) in my Sulfur Metabolism
Deficient sulfoxidation enzymes
Sulfite Oxidase (SO) - catalyses the oxidation of sulfite to sulfate, necessary for metabolism of sulfur amino acids.
It's clear I have inadequate sulfate. But could this be from deficient CDO alone? What proportion of the body's sulfate comes from CDO, what from SO?
Dysfunctional Sulfation (Inorganic sulfate is activated with two ATP molecules, producing phosphoadenosyl phosphosulfate (PAPS) which then reacts with exotoxins to produce sulfated derivatives.) Just above reference range on GS test. For more info see Sulfation.
Deficient Glutathione Conjugation: The Detox Profile showed my Glutathione Conjugation too low, but glutathione reserves were not exhausted.
Deficient Glycine Conjugation and as a result, too high a ratio of Phase I detoxification to glycine conjugation making me a "pathological detoxifier": My P450 enzymes make their toxic products too fast for my glycination to handle. Glycine, and the other amino acids used for conjugation, become deficient on a low-protein diet and when chronic exposure to toxins results in depletion. Supplement? Jo-Mar Labs has a pure powder of it [scroll down in their "Amino Acid Quick Finder"].
Deficient bile from lack of taurine: stools become more yellow, less brown. Fat digestion suffers.
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Last updated 8 June 2007